Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | GCKR | Q14397 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828517 | 0.94 | MAPT (0.50) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL30419374 | 0.90 | NR1H2 (0.42) | MAPTALDH1A1LMNASMN1; SMN2GPR119 | |
| SCHEMBL1990092 | 0.90 | NR1H2 (0.42) | MAPTALDH1A1LMNASMN1; SMN2GPR119 | |
| SCHEMBL9068219 | 0.89 | MAPT (0.45) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL30558295 | 0.84 | MAPT (0.49) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL27031050 | 0.84 | MAPT (0.49) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL20838955 | 0.84 | MAPT (0.49) | MAPTALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL5724734 | 0.80 | MAPT (0.68) | MAPTALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL27676282 | 0.80 | MAPT (0.53) | MAPTSMN1; SMN2RAB9APOLBCHRNB2 | |
| SCHEMBL20839065 | 0.79 | JAK3 (0.46) | MAPTALDH1A1LMNASMN1; SMN2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470124-A1 | 2-(PYRIDIN-2-YLAMINO)-PYRIDO 2,3-d]PYRIMIDIN-7-ONES | Warner-Lambert Company LLC (US) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003062236-A1 | 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY LLC (US) | 2003-07-31 | — | — | WO | disclosed |