Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20838955 | 1.00 | MAPT (0.49) | MAPTSMN1; SMN2ALDH1A1LMNARAB9A | |
| SCHEMBL27031050 | 1.00 | MAPT (0.49) | MAPTSMN1; SMN2ALDH1A1LMNARAB9A | |
| SCHEMBL4828517 | 0.89 | MAPT (0.50) | MAPTSMN1; SMN2ALDH1A1LMNARAB9A | |
| SCHEMBL18186271 | 0.84 | MAPT (0.65) | MAPTSMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL9068219 | 0.84 | MAPT (0.45) | MAPTSMN1; SMN2ALDH1A1LMNARAB9A | |
| SCHEMBL6675465 | 0.84 | MAPT (0.45) | MAPTSMN1; SMN2ALDH1A1LMNARAB9A | |
| SCHEMBL20839065 | 0.83 | JAK3 (0.46) | MAPTSMN1; SMN2ALDH1A1LMNAJAK3 | |
| SCHEMBL20838957 | 0.83 | JAK3 (0.44) | MAPTSMN1; SMN2ALDH1A1LMNAJAK3 | |
| SCHEMBL30558294 | 0.83 | JAK3 (0.44) | MAPTSMN1; SMN2ALDH1A1LMNAJAK3 | |
| SCHEMBL30558296 | 0.83 | JAK3 (0.46) | MAPTSMN1; SMN2ALDH1A1LMNAJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118005654-A | Substituted pyridopyrimidinone compounds, compositions containing the same and uses thereof | 深圳市塔吉瑞生物医药有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117050096-A | Preparation method of risperidone | 杭州诺澳生物医药科技有限公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-117015546-A | Process for preparing Li Sipu blue | 豪夫迈·罗氏有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-111132981-B | Process for preparing pyrido [1,2-A ] pyrimidin-4-one derivatives | 豪夫迈·罗氏有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-116813648-A | Process for preparing 2- (2, 8-dimethylimidazo [1,2-B ] pyridazin-6-yl) pyrido [1,2-a ] pyrimidin-4-one derivatives | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |