Sugi Predict

Sugi Predict / Compounds / Hydroxyamine

Hydroxyamine

Hydroxyamine

SCHEMBL6675656

CC#CCOc1ccc(S(=O)(=O)C(CCCCNC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)C(=O)O)cc1.NO

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ ADAM17 P78536 20/20 0.52
▸ MMP13 P45452 10/20 0.52
▸ MMP9 P14780 10/20 0.52
▸ MMP1 P03956 8/20 0.52
▸ MMP2 P08253 2/20 0.42
▸ MMP14 P50281 2/20 0.42
▸ ADAM10 O14672 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6675657 0.92 ADAM17 (0.51) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL3937334 0.92 ADAM17 (0.64) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL3946154 0.85 ADAM17 (0.69) ADAM17MMP13MMP9MMP1MMP2
Hydroxyamine SCHEMBL4020413 0.81 ADAM17 (0.54) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL3939497 0.78 ADAM17 (0.74) ADAM17MMP13MMP9MMP1MMP14
SCHEMBL3948420 0.78 ADAM17 (0.47) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL3939996 0.78 ADAM17 (0.63) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL3948475 0.77 ADAM17 (0.61) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL3948467 0.76 ADAM17 (0.57) ADAM17MMP13MMP9MMP1MMP2
SCHEMBL6654717 0.75 ADAM17 (0.78) ADAM17MMP13MMP9MMP1MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1147080-B1 ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS WYETH CORP (US) 2004-07-21 — — EP disclosed