SCHEMBL6675729

SCHEMBL6675729

CN1CCC(Oc2cc(NS(=O)(=O)c3cccc4cccnc34)ccc2C(F)(F)F)C1

nearest known ligand 0.64

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 10/20 0.64
HTR6 P50406 1/20 0.56
GHSR Q92847 1/20 0.51
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
PKLR P30613 1/20 0.47
BRD4 O60885 1/20 0.47
TP53 P04637 1/20 0.47
HTT P42858 1/20 0.47
GFER P55789 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6675724 1.00 UTS2R (0.64) UTS2RHTR6GHSRMEN1KMT2A
SCHEMBL8337458 0.86 UTS2R (0.68) UTS2RHTR6GHSR
SCHEMBL6676187 0.86 UTS2R (0.68) UTS2RHTR6GHSR
SCHEMBL6676194 0.86 UTS2R (0.68) UTS2RHTR6GHSR
SCHEMBL8342929 0.85 UTS2R (0.73) UTS2RBRD4
SCHEMBL6685830 0.84 UTS2R (0.63) UTS2RMEN1KMT2AHTT
SCHEMBL6687721 0.84 UTS2R (0.63) UTS2RMEN1KMT2ATP53
SCHEMBL8337677 0.82 UTS2R (0.67) UTS2RHTR6
SCHEMBL5835498 0.81 UTS2R (0.86) UTS2R
SCHEMBL5835493 0.81 UTS2R (0.86) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043369-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO claimed
WO-2004043369-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed