SCHEMBL8337677

SCHEMBL8337677

Cc1cccc2c(S(=O)(=O)Nc3ccc(C(F)(F)F)c(O[C@H]4CCN(C)C4)c3)cccc12

nearest known ligand 0.67

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.67
HTR6 P50406 2/20 0.43
FABP4 P15090 1/20 0.39
FABP5 Q01469 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6672599 0.90 UTS2R (0.66) UTS2RHTR6
SCHEMBL6676194 0.90 UTS2R (0.68) UTS2RHTR6
SCHEMBL8337458 0.90 UTS2R (0.68) UTS2RHTR6
SCHEMBL6676187 0.90 UTS2R (0.68) UTS2RHTR6
SCHEMBL6672873 0.89 UTS2R (0.64) UTS2RHTR6
SCHEMBL8338096 0.89 UTS2R (0.64) UTS2RHTR6
SCHEMBL6677101 0.89 UTS2R (0.64) UTS2RHTR6
SCHEMBL8342929 0.87 UTS2R (0.73) UTS2R
SCHEMBL8337844 0.84 UTS2R (0.70) UTS2R
SCHEMBL6675124 0.84 UTS2R (0.65) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043369-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed