Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18074831 | 0.91 | PARP1 (0.41) | HTTL3MBTL1ALDH1A1TDP1HSP90AA1 | |
| SCHEMBL6679170 | 0.85 | CYP2A6 (0.54) | HTTL3MBTL1ALDH1A1TDP1HSP90AA1 | |
| SCHEMBL3667468 | 0.79 | PARP1 (0.45) | HTTL3MBTL1ALDH1A1CHEK1LMNA | |
| SCHEMBL8675092 | 0.73 | ALDH1A1 (0.56) | HTTL3MBTL1ALDH1A1TDP1CHEK1 | |
| SCHEMBL787084 | 0.73 | PRKCI (0.51) | HTTL3MBTL1ALDH1A1TDP1HSP90AA1 | |
| SCHEMBL6679876 | 0.72 | PADI4 (0.41) | HTTL3MBTL1ALDH1A1KMT2ACHEK1 | |
| SCHEMBL2763150 | 0.72 | CDC7 (0.39) | HTTL3MBTL1ALDH1A1KMT2ANPSR1 | |
| SCHEMBL3667347 | 0.72 | MAPK14 (0.42) | HTTALDH1A1CHEK1KDM4EMAPT | |
| SCHEMBL6674838 | 0.72 | CYP2A6 (0.55) | P4HTMNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1888457 | 0.71 | PRMT5 (0.43) | HTTL3MBTL1ALDH1A1TDP1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |