Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6682248 | 0.90 | ALDH1A1 (0.40) | ALDH1A1GAASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6679793 | 0.87 | ALDH1A1 (0.35) | ALDH1A1GAASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6675695 | 0.85 | ALDH1A1 (0.39) | ALDH1A1GAASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6678474 | 0.85 | ALDH1A1 (0.39) | ALDH1A1GAASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6678436 | 0.84 | ALDH1A1 (0.40) | ALDH1A1GAAKMT2AMCHR1HPGD | |
| SCHEMBL6681804 | 0.84 | GRM2 (0.38) | ALDH1A1GAASMN1; SMN2MAPTKMT2A | |
| SCHEMBL27544112 | 0.84 | ALDH1A1 (0.39) | ALDH1A1GAASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6676380 | 0.83 | ALDH1A1 (0.37) | ALDH1A1GAASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6676359 | 0.81 | ALDH1A1 (0.36) | ALDH1A1GAASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6676234 | 0.81 | ALDH1A1 (0.39) | ALDH1A1MAPTKMT2AHTTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |