SCHEMBL6677172

SCHEMBL6677172

CCOC(=O)c1cccc2c1CC(C)(C)O2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.50
ALDH1A1 P00352 5/20 0.44
HSD17B10 Q99714 3/20 0.44
MAPT P10636 3/20 0.42
GLA P06280 1/20 0.42
HPGD P15428 2/20 0.42
HTT P42858 1/20 0.42
CDC25B P30305 2/20 0.42
GAA P10253 2/20 0.41
KDM4E B2RXH2 2/20 0.41
CASP1 P29466 1/20 0.41
OPRM1 P35372 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15761256 0.79 LMNA (0.40) ALDH1A1MAPTKDM4ENPSR1
SCHEMBL2434076 0.78 LMNA (0.52) TSHRALDH1A1HSD17B10MAPTKDM4E
SCHEMBL22032130 0.76 TSHR (0.41) TSHRALDH1A1HSD17B10MAPTHPGD
SCHEMBL17535601 0.76 TSHR (0.41) TSHRALDH1A1HSD17B10MAPTGLA
SCHEMBL6676925 0.72 TSHR (0.50) TSHRALDH1A1HSD17B10MAPTHPGD
SCHEMBL899854 0.71 TSHR (0.53) TSHRALDH1A1HSD17B10MAPTGLA
SCHEMBL6677783 0.71 TSHR (0.49) TSHRALDH1A1HSD17B10MAPTGLA
SCHEMBL15761205 0.71 CCR8 (0.34) ALDH1A1MAPTKDM4ENPSR1MEN1
SCHEMBL11921725 0.70 TSHR (0.47) TSHRALDH1A1HSD17B10MAPTCDC25B
SCHEMBL16414281 0.70 TSHR (0.51) TSHRALDH1A1HSD17B10MAPTGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027043-B1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2004-11-10 EP disclosed
EP-1027043-A4 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2002-02-20 EP disclosed
EP-1027043-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS Bristol-Myers Squibb Company (US) 2000-08-16 EP disclosed
US-6060506-A FOR TREATMENT OF SLEEP DISORDERS, CIRCADIAN RHYTHM DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-09 US disclosed
US-5981571-A USEFUL AS MELATONERGIC AGENTS IN THE TREATMENT OF SLEEP DISORDERS, SEASONAL DEPRESSION, SHIFTS IN CIRCADIAN CYCLES, MELANCHOLIA, STRESS, APPETITE REGULATION, BENIGN PROSTATIC HYPERPLASIA AND RELATED CONDITIONS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-11-09 US disclosed
US-5856529-A ADJUSTMENT OF NERVOUS SYSTEM, ENDOCRINE FUNCTION; REPRODUCTION, BODY WEIGHT AND METABOLISM BRISTOL-MYERS SQUIBB COMPANY (US) 1999-01-05 US disclosed
WO-1998025606-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-06-18 WO disclosed