Morpholine

Morpholine

SCHEMBL6677436

C1COCCN1.Cc1cccc([N+](=O)[O-])c1[N+](=O)[O-]

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.68
TDP1 Q9NUW8 5/20 0.51
ALDH1A1 P00352 3/20 0.51
SMN1; SMN2 Q16637 1/20 0.47
HSD17B10 Q99714 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.45
GPR35 Q9HC97 1/20 0.42
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
MAPT P10636 2/20 0.38
PKM P14618 1/20 0.38
NPC1 O15118 1/20 0.37
MAPK1 P28482 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
GAA P10253 2/20 0.36
MGAM O43451 1/20 0.36
SI P14410 1/20 0.36
MGAM2 Q2M2H8 1/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Morpholine SCHEMBL7074183 0.86 HSD17B10 (0.65) TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10
Fluoride SCHEMBL28054250 0.84 TSHR (0.96) TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10
SCHEMBL146895 0.82 TSHR (1.00) TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10
SCHEMBL1101208 0.82 TSHR (1.00) TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10
SCHEMBL29359563 0.82 TSHR (1.00) TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10
Morpholine SCHEMBL4870083 0.81 MAPT (0.49) TSHRTDP1ALDH1A1HSD17B10GPR35
Magnesium SCHEMBL11696142 0.81 TSHR (0.96) TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10
SCHEMBL28589645 0.81 TSHR (0.96) TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10
SCHEMBL11696134 0.81 TSHR (0.96) TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10
SCHEMBL8717819 0.81 TSHR (0.96) TSHRTDP1ALDH1A1SMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003048226-A9 LUMINESCENT POLYMER PARTICLES NOMADICS INC (US) 2004-04-22 WO disclosed
WO-2003048226-A2 LUMINESCENT POLYMER PARTICLES NOMADICS, INC. (US) 2003-06-12 WO disclosed