Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 13/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11399599 | 0.91 | IDO1 (0.83) | IDO1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL6541555 | 0.82 | IDO1 (0.69) | IDO1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL31006473 | 0.82 | IDO1 (0.69) | IDO1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL11511910 | 0.79 | IDO1 (0.66) | IDO1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL12599061 | 0.77 | IDO1 (1.00) | IDO1CHEK1PIM1LTKLIMK1 | |
| SCHEMBL9750717 | 0.76 | IDO1 (0.61) | IDO1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL268673 | 0.76 | KDM4E (0.78) | IDO1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL12086889 | 0.76 | IDO1 (0.61) | IDO1CHEK1PIM1LTKLIMK1 | |
| Hydrochloric Acid SCHEMBL6266755 | 0.75 | KDM4E (0.75) | IDO1KDM4EMEN1ALDH1A1MAPT | |
| Bromide SCHEMBL10436174 | 0.75 | KDM4E (0.75) | IDO1KDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9486422-B2 | Small molecule inhibitors of Mcl-1 and the uses of thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-08 | — | — | US | disclosed |
| US-20140235702-A1 | SMALL MOLECULE INHIBITORS OF MCL-1 AND THE USES OF THEREOF | WAYNE STATE UNIVERSITY | 2014-08-21 | — | — | US | disclosed |
| US-20110112282-A1 | IDO INHIBITORS AND THERAPEUTIC USES THEREOF | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. | 2011-05-12 | — | — | US | disclosed |
| US-20110112282-A1 | IDO INHIBITORS AND THERAPEUTIC USES THEREOF | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. | 2011-05-12 | — | — | US | disclosed |
| EP-1248603-B1 | USE OF PARTICULAR COMPOUNDS FOR PROPHYLAXIS AND TREATMENT OF HEPATITIS C | MORPHOCHEM AG (DE) | 2004-10-13 | — | — | EP | disclosed |
| US-20030153594-A1 | Use of particular compounds for prophylaxis and treatment of hepatitis c | MORPHOCHEM AG (DE) | 2003-08-14 | — | — | US | disclosed |
| EP-1248603-A2 | USE OF PARTICULAR COMPOUNDS FOR PROPHYLAXIS AND TREATMENT OF HEPATITIS C | Morphochem AG (DE) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001052824-A2 | USE OF PARTICULAR COMPOUNDS FOR PROPHYLAXIS AND TREATMENT OF HEPATITIS C | MORPHOCHEM AG (DE) | 2001-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153594-A1 | Use of particular compounds for prophylaxis and treatment of hepatitis c | HAVCR2, CBR1, HCCS | IDO1 646/4885CHEK1 1183/4885PIM1 4718/4885 |
| US-20110112282-A1 | IDO INHIBITORS AND THERAPEUTIC USES THEREOF | IDO1, IDO2, IDH3B | IDO1 1/4885CHEK1 3523/4885PIM1 1831/4885 |
| US-20140235702-A1 | SMALL MOLECULE INHIBITORS OF MCL-1 AND THE USES OF THEREOF | MCL1, BCL2L1, BCL2L11 | IDO1 2378/4885CHEK1 1119/4885PIM1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.