Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.51 |
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | CPA1 | P15085 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | ACP3 | P15309 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3814684 | 0.93 | CTNNB1 (0.56) | CTNNB1TDP1HRH4CYP1A2SLC1A3 | |
| SCHEMBL7352579 | 0.93 | CYP1A2 (0.65) | CTNNB1TDP1HRH4CYP1A2SLC1A3 | |
| SCHEMBL7267021 | 0.91 | CTNNB1 (0.58) | CTNNB1TDP1HRH4CYP1A2SLC1A3 | |
| SCHEMBL7287691 | 0.91 | CTNNB1 (0.58) | CTNNB1TDP1HRH4CYP1A2SLC1A3 | |
| SCHEMBL7268294 | 0.91 | CTNNB1 (0.58) | CTNNB1TDP1HRH4CYP1A2SLC1A3 | |
| SCHEMBL4620167 | 0.90 | CTNNB1 (0.56) | CTNNB1TDP1HRH4CYP1A2SLC1A3 | |
| SCHEMBL6444456 | 0.90 | CTNNB1 (0.56) | CTNNB1TDP1HRH4CYP1A2SLC1A3 | |
| SCHEMBL7429100 | 0.90 | CPA1 (0.57) | CTNNB1TDP1HRH4CYP1A2SLC1A3 | |
| SCHEMBL9194477 | 0.90 | CPA1 (0.57) | CTNNB1TDP1HRH4CYP1A2SLC1A3 | |
| SCHEMBL10338654 | 0.90 | CPA1 (0.57) | CTNNB1TDP1HRH4CYP1A2SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275480-A2 | Renin inhibitors IV | WARNER-LAMBERT COMPANY (US) | 1988-07-27 | — | — | EP | claimed |
| EP-0736036-B1 | KININOGEN INHIBITORS | FERRING BV (NL) | 2004-10-13 | — | — | EP | disclosed |
| US-6008372-A | ANTICARCINOGENIC, ANTIRESTENOSIS AND ANTIPSORIASIS AGENT | WARNER-LAMBERT COMPANY (US) | 1999-12-28 | — | — | US | disclosed |
| US-5844078-A | Phenyl peptides, method for preparing same, and pharmaceutical compositions containing said peptides | LABORATORIE LAPHAL (FR) | 1998-12-01 | — | — | US | disclosed |
| WO-1997026246-A1 | SUBSTITUTED HISTIDINE INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-07-24 | — | — | WO | disclosed |
| US-5610177-A | Acylated amino acids as endothelin antagonists | WARNER-LAMBERT COMPANY (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0736036-A1 | KININOGEN INHIBITORS | FERRING B.V. (NL) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995007291-A1 | KININOGEN INHIBITORS | FERRING B.V. (NL) | 1995-03-16 | — | — | WO | disclosed |
| US-5360791-A | Renin-inhibiting aminodiol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-01 | — | — | US | disclosed |
| EP-0370454-B1 | Renin-inhibiting amino diol derivatives | HOECHST AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| WO-1989003820-A1 | BRANCHED BACKBONE RENIN INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-05-05 | — | — | WO | disclosed |
| EP-0309841-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1989-04-05 | — | — | EP | disclosed |
| US-4804743-A | HYPOTENSIVE AGENTS, ANTIALDOSTERONES | Warner-Lambert Copmany (US) | 1989-02-14 | — | — | US | disclosed |
| EP-0275480-A2 | Renin inhibitors IV | WARNER-LAMBERT COMPANY (US) | 1988-07-27 | — | — | EP | disclosed |
| EP-0271862-A2 | Renin inhibitors III | WARNER-LAMBERT COMPANY (US) | 1988-06-22 | — | — | EP | disclosed |
| US-4735933-A | HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0255082-A2 | Renin-inhibiting di- and tripeptides, methods for their production, drugs containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-03 | — | — | EP | disclosed |
| EP-0252727-A1 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-01-13 | — | — | EP | disclosed |
| EP-0228192-A2 | Renin-inhibitory oligopeptides, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1987-07-08 | — | — | EP | disclosed |
| EP-0186977-A2 | Renin-inhibitory dipeptides, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1986-07-09 | — | — | EP | disclosed |