Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678135 | 0.90 | TSHR (0.35) | TSHRADORA3ALDH1A1ATMKMT2A | |
| SCHEMBL6679649 | 0.86 | CACNA1D (0.35) | ALDH1A1CACNA1DPOLBSMN1; SMN2HTT | |
| SCHEMBL6682470 | 0.83 | TSHR (0.36) | TSHRADORA3ALDH1A1ATMKMT2A | |
| SCHEMBL1681836 | 0.81 | TSHR (0.42) | TSHRADORA3ALDH1A1ATMKMT2A | |
| SCHEMBL6681181 | 0.75 | PDK2 (0.32) | TSHRADORA3ALDH1A1KMT2AKDM4E | |
| SCHEMBL6678306 | 0.75 | CACNA1D (0.33) | ALDH1A1CACNA1DPOLBHSD17B10 | |
| SCHEMBL6677411 | 0.70 | ATM (0.33) | TSHRADORA3ALDH1A1ATMKMT2A | |
| SCHEMBL13228931 | 0.69 | TSHR (0.52) | TSHRADORA3ALDH1A1KMT2AKDM4E | |
| SCHEMBL6679547 | 0.68 | HDAC4 (0.33) | POLBGAA | |
| SCHEMBL6680769 | 0.67 | SLC9A1 (0.34) | CACNA1DCYP3A4SMN1; SMN2HTTHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |