Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677920 | 1.00 | CCR6 (0.46) | CCR6HSP90AA1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL6678575 | 0.91 | HSP90AA1 (0.47) | CCR6HSP90AA1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL6678587 | 0.91 | HSP90AA1 (0.47) | CCR6HSP90AA1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL6677864 | 0.87 | HSP90AA1 (0.49) | CCR6HSP90AA1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL6677866 | 0.87 | HSP90AA1 (0.49) | CCR6HSP90AA1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL2969421 | 0.81 | HSP90AA1 (0.55) | CCR6HSP90AA1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL6718866 | 0.81 | CCR6 (0.48) | CCR6HSP90AA1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL6677987 | 0.81 | HSP90AA1 (0.48) | CCR6HSP90AA1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL6677991 | 0.81 | CCR6 (0.48) | CCR6HSP90AA1SLC6A2SLC6A4OPRM1 | |
| SCHEMBL6677339 | 0.81 | HSP90AA1 (0.48) | CCR6HSP90AA1SLC6A2SLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246793-B1 | SUBSTITUTED AMINOMETHYL-PHENYL-CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-11-10 | — | — | EP | claimed |
| US-6673794-B2 | ANALGESICS, INCOTINENCE, SKIN DISORDERS, ANTIINFLAMMATORY AGENTS | GRUENENTHAL GMBH (DE) | 2004-01-06 | — | — | US | claimed |
| US-20030069288-A1 | Substituted aminomethyl-phenyl-cyclohexane derivatives | GRUENETHAL GMBH (DE) | 2003-04-10 | — | — | US | claimed |
| EP-1246793-B1 | SUBSTITUTED AMINOMETHYL-PHENYL-CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-11-10 | — | — | EP | disclosed |
| US-6673794-B2 | ANALGESICS, INCOTINENCE, SKIN DISORDERS, ANTIINFLAMMATORY AGENTS | GRUENENTHAL GMBH (DE) | 2004-01-06 | — | — | US | disclosed |
| US-20030069288-A1 | Substituted aminomethyl-phenyl-cyclohexane derivatives | GRUENETHAL GMBH (DE) | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069288-A1 | Substituted aminomethyl-phenyl-cyclohexane derivatives | PTGER1, CYP2E1, HRH2 | CCR6 1317/4885HSP90AA1 1652/4885SLC6A2 1542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.