Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | CCR6 | P51684 | 1/20 | 0.55 |
| ▸ | METAP1 | P53582 | 3/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6293297 | 0.99 | HSP90AA1 (0.57) | HSP90AA1CCR6METAP1NCOA1NCOA3 | |
| SCHEMBL7595498 | 0.96 | HSP90AA1 (0.52) | HSP90AA1CCR6METAP1NCOA1NCOA3 | |
| SCHEMBL6293299 | 0.86 | METAP1 (0.46) | HSP90AA1CCR6METAP1SLC6A2SLC6A4 | |
| SCHEMBL6677864 | 0.84 | HSP90AA1 (0.49) | HSP90AA1CCR6METAP1HTR1AHTR7 | |
| SCHEMBL6681699 | 0.84 | HSP90AA1 (0.47) | HSP90AA1CCR6METAP1HTR1AHTR7 | |
| SCHEMBL6677866 | 0.84 | HSP90AA1 (0.49) | HSP90AA1CCR6METAP1HTR1AHTR7 | |
| SCHEMBL6297691 | 0.84 | METAP1 (0.45) | HSP90AA1CCR6METAP1MEN1KMT2A | |
| SCHEMBL6298674 | 0.84 | ADRA2A (0.41) | HSP90AA1CCR6SLC6A2SLC6A4OPRM1 | |
| SCHEMBL6294523 | 0.84 | HSP90AA1 (0.40) | HSP90AA1CCR6HTR1AHTR7SLC6A4 | |
| SCHEMBL6293028 | 0.83 | METAP1 (0.41) | HSP90AA1CCR6METAP1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890959-B2 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2005-05-10 | — | — | US | claimed |
| EP-1246791-B1 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-10-27 | — | — | EP | claimed |
| US-20030096811-A1 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2003-05-22 | — | — | US | claimed |
| EP-1246791-A2 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | claimed |
| US-6274768-B1 | 4-(DIHYDROCARBYLAMINO)-3-PHENYLCYCLOHEXANONE INTERMEDIATES | GRUENENTHAL GMBH (DE) | 2001-08-14 | — | — | US | claimed |
| WO-2001049651-A2 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2001-07-12 | — | — | WO | claimed |
| EP-2262759-A1 | METHOD FOR THE PRODUCTION OF (1RS,3RS,6RS)-6-DIMETHYL AMINO ETHYL-1-(3-METHOXY PHENYL)-CYCLOHEXANE-1,3-DIOL | Grünenthal GmbH (DE) | 2010-12-22 | — | — | EP | disclosed |
| US-7763754-B2 | Process for producing (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol | GRUENENTHAL GMBH (DE) | 2010-07-27 | — | — | US | disclosed |
| US-20090253936-A1 | Reacting 3-dimethylamino-1-(3-methoxyphenyl)-propan-1-one with an alpha , beta -unsaturated ketone to form 2-dimethylaminomethyl-1-(3-methoxyphenyl)hexane-1,5-dione andand cyclizing the 2-dimethylaminomethyl-1-(3-methoxyphenyl)hexane-1,5-dione; stereoisomers; catalyst selectivity; analgesics | GRUENENTHAL GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
| WO-2009106336-A1 | METHOD FOR THE PRODUCTION OF (1RS,3RS,6RS)-6-DIMETHYL AMINO ETHYL-1-(3-METHOXY PHENYL)-CYCLOHEXANE-1,3-DIOL | Grünenthal GmbH (DE) | 2009-09-03 | — | — | WO | disclosed |
| US-6890959-B2 | Aminomethyl-phenyl-cyclohexanone derivatives | GRUENENTHAL GMBH (DE) | 2005-05-10 | — | — | US | disclosed |
| EP-1246793-B1 | SUBSTITUTED AMINOMETHYL-PHENYL-CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-11-10 | — | — | EP | disclosed |
| EP-1246791-B1 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-10-27 | — | — | EP | disclosed |
| EP-1246793-A2 | SUBSTITUTED AMINOMETHYL-PHENYL-CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| EP-1246791-A2 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| US-6274768-B1 | 4-(DIHYDROCARBYLAMINO)-3-PHENYLCYCLOHEXANONE INTERMEDIATES | GRUENENTHAL GMBH (DE) | 2001-08-14 | — | — | US | disclosed |
| WO-2001049651-A2 | AMINOMETHYL-PHENYL-CYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2001-07-12 | — | — | WO | disclosed |
| WO-2001049654-A2 | SUBSTITUTED AMINOMETHYL-PHENYL-CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2001-07-12 | — | — | WO | disclosed |
| US-6077845-A | AS ANALGESIC FOR ALLEVIATING PAIN | GRUENENTHAL GMBH (DE) | 2000-06-20 | — | — | US | disclosed |
| EP-0970949-A1 | Acridine derivatives | Grünenthal GmbH (DE) | 2000-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253936-A1 | Reacting 3-dimethylamino-1-(3-methoxyphenyl)-propan-1-one with an alpha , beta -unsaturated ketone to form 2-dimethylaminomethyl-1-(3-methoxyphenyl)hexane-1,5-dione andand cyclizing the 2-dimethylaminomethyl-1-(3-methoxyphenyl)hexane-1,5-dione; stereoisomers; catalyst selectivity; analgesics | OPRD1, OPRK1, OPRM1 | HSP90AA1 1851/4885CCR6 853/4885METAP1 442/4885 |
| US-20030096811-A1 | Aminomethyl-phenyl-cyclohexanone derivatives | CYP2J2, CYP2E1, CYP2D6 | HSP90AA1 1369/4885CCR6 970/4885METAP1 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.