Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687978 | 1.00 | MAPT (0.47) | MAPTSMN1; SMN2CYP1A1CYP1B1MAPK1 | |
| SCHEMBL6688949 | 0.96 | MAPK1 (0.49) | MAPTSMN1; SMN2MAPK1ALDH1A1HTT | |
| SCHEMBL6683009 | 0.93 | MAPK1 (0.52) | MAPTSMN1; SMN2MAPK1ALDH1A1HTT | |
| SCHEMBL6691771 | 0.93 | MAPT (0.47) | MAPTSMN1; SMN2MAPK1ALDH1A1HTT | |
| SCHEMBL6678974 | 0.93 | MAPT (0.47) | MAPTSMN1; SMN2MAPK1ALDH1A1HTT | |
| SCHEMBL6684426 | 0.90 | MAPT (0.50) | MAPTSMN1; SMN2MAPK1ALDH1A1HTT | |
| SCHEMBL6689377 | 0.90 | MAPT (0.50) | MAPTSMN1; SMN2MAPK1ALDH1A1HTT | |
| SCHEMBL6689603 | 0.89 | MAPK1 (0.48) | MAPTSMN1; SMN2CYP1A1CYP1B1MAPK1 | |
| SCHEMBL6684355 | 0.89 | CYP1A1 (0.50) | MAPTSMN1; SMN2CYP1A1CYP1B1MAPK1 | |
| SCHEMBL6687644 | 0.88 | MAPK1 (0.48) | MAPTSMN1; SMN2MAPK1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043951-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | CAREX S.A. (FR) | 2004-05-27 | — | — | WO | claimed |
| WO-2004043951-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | CAREX S.A. (FR) | 2004-05-27 | — | — | WO | disclosed |