Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.79 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.79 |
| ▸ | TTR | P02766 | 1/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.79 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.79 |
| ▸ | PPARG | P37231 | 1/20 | 0.79 |
| ▸ | HTR2B | P41595 | 1/20 | 0.79 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.79 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.79 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.79 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.53 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30504804 | 1.00 | PPARA (0.79) | PPARACYP2C9TSHRSMN1; SMN2CYP2C8 | |
| SCHEMBL9416380 | 0.96 | PPARA (0.72) | PPARACYP2C9TSHRSMN1; SMN2CYP2C8 | |
| Gemfibrozil SCHEMBL20770039 | 0.88 | PPARA (1.00) | PPARACYP2C9TSHRSMN1; SMN2CYP2C8 | |
| Gemfibrozil SCHEMBL1880616 | 0.88 | PPARA (1.00) | PPARACYP2C9TSHRSMN1; SMN2CYP2C8 | |
| Gemfibrozil SCHEMBL4813 | 0.88 | PPARA (1.00) | PPARACYP2C9TSHRSMN1; SMN2CYP2C8 | |
| Gemfibrozil SCHEMBL29398115 | 0.88 | PPARA (1.00) | PPARACYP2C9TSHRSMN1; SMN2CYP2C8 | |
| Gemfibrozil SCHEMBL10542601 | 0.87 | PPARA (0.97) | PPARACYP2C9TSHRSMN1; SMN2CYP2C8 | |
| SCHEMBL11094581 | 0.87 | PPARA (0.64) | PPARACYP2C9TSHRSMN1; SMN2CYP2C8 | |
| Gemfibrozil SCHEMBL21052128 | 0.87 | PPARA (0.97) | PPARACYP2C9TSHRSMN1; SMN2CYP2C8 | |
| Gemfibrozil SCHEMBL457931 | 0.87 | PPARA (0.97) | PPARACYP2C9TSHRSMN1; SMN2CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332995-A | Nucleotide derivative, pharmaceutical composition and application thereof | 南京知和医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |
| WO-2004043951-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | CAREX S.A. (FR) | 2004-05-27 | — | — | WO | disclosed |
| WO-2004037248-A2 | MODULATION OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ACTIVITY | CAREX SA (FR) | 2004-05-06 | — | — | WO | disclosed |
| US-RE37770-E1 | SUCH AS LINOLEIC ACID, OLEIC ACID, 5,8,11,14-EICOSATETRAYNOIC ACID, 4-CHLORO-6-(2,3-XYLIDINO)-2-PYRIMIDINYL)THIOACETIC ACID, CLOFIBRATE, AND GEMFIBROZIL; USEFUL FOR TREATING DISORDERS OF EPIDERMAL DIFFERENTIATION AND PROLIFERATION. | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-06-25 | — | — | US | disclosed |
| US-6187814-B1 | BY TOPICALLY AN FARNESOID X-ACTIVATED RECEPTOR (FXR) ACTIVATOR SELECTED FROM FARNESAL, ALKYL FARNESYL ETHER, ALKYL FARNESOATE, AND 7-METHYL-9-(3,3-DIMETHYLOXIRANYL)-3-METHYL-2,6-NONADIENOIC ACID, ALKYL ESTER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-02-13 | — | — | US | disclosed |
| US-6184215-B1 | TOPICALLY APPLYING TO SKIN A HYDROXYCHOLESTEROL TO ACTIVATE LIVER-BASED X-ACTIVATED RECEPTOR ALPHA (LXRA) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-02-06 | — | — | US | disclosed |
| US-6071955-A | TREATING TERRESTRIAL MAMMALIAN SUBJECT SUFFERING FROM A CONDITIONS OF ACNE AND ACNEIFORM CONDITIONS BY ADMINISTERING 7-METHYL-9-(3,3-DIMETHYLOXIRANYL)-3-METHYL-2,6-NONADIENOIC ACID METHYL ESTER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-06-06 | — | — | US | disclosed |
| US-6060515-A | TOPICALLY APPLYING TO MAMMALIAN SKIN OR MUCOUS MEMBRANE A BARRIER DEVELOPMENT ENHANCING AMOUNT OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARA) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-05-09 | — | — | US | disclosed |