SCHEMBL6678093

SCHEMBL6678093

CN(CC1CC1c1cccc2occc12)C(N)=O

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 6/20 0.44
SLC6A2 P23975 4/20 0.44
SLC6A3 Q01959 4/20 0.44
ALOX5 P09917 2/20 0.43
OPRM1 P35372 1/20 0.39
OPRK1 P41145 1/20 0.39
HTR2A P28223 3/20 0.37
DRD2 P14416 1/20 0.37
DRD3 P35462 1/20 0.37
MTNR1A P48039 2/20 0.37
MTNR1B P49286 2/20 0.37
HTR2C P28335 2/20 0.37
HTR2B P41595 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6678094 1.00 SLC6A4 (0.44) SLC6A4SLC6A2SLC6A3ALOX5OPRM1
SCHEMBL6677230 0.76 HTR2C (0.53) HTR2AHTR2CHTR2B
SCHEMBL6677231 0.76 HTR2C (0.53) HTR2AHTR2CHTR2B
SCHEMBL8490211 0.76 HTR2A (0.35) SLC6A4SLC6A2SLC6A3ALOX5OPRM1
SCHEMBL6678064 0.75 MTNR1B (0.57) SLC6A4HTR2ADRD2DRD3MTNR1A
SCHEMBL6678071 0.75 MTNR1B (0.57) SLC6A4HTR2ADRD2DRD3MTNR1A
SCHEMBL6680487 0.75 MTNR1B (0.59) SLC6A4MTNR1AMTNR1B
SCHEMBL6680484 0.75 MTNR1B (0.59) SLC6A4MTNR1AMTNR1B
SCHEMBL8489167 0.73 SLC6A2 (0.40) SLC6A4SLC6A2SLC6A3OPRM1OPRK1
SCHEMBL8486794 0.73 SLC6A4 (0.40) SLC6A4SLC6A2SLC6A3ALOX5OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027043-B1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2004-11-10 EP disclosed
EP-1027043-A4 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2002-02-20 EP disclosed
EP-1027043-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS Bristol-Myers Squibb Company (US) 2000-08-16 EP disclosed
US-6060506-A FOR TREATMENT OF SLEEP DISORDERS, CIRCADIAN RHYTHM DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-09 US disclosed
US-5981571-A USEFUL AS MELATONERGIC AGENTS IN THE TREATMENT OF SLEEP DISORDERS, SEASONAL DEPRESSION, SHIFTS IN CIRCADIAN CYCLES, MELANCHOLIA, STRESS, APPETITE REGULATION, BENIGN PROSTATIC HYPERPLASIA AND RELATED CONDITIONS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-11-09 US disclosed
WO-1998025606-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-06-18 WO disclosed