Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.55 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.55 |
| ▸ | DPP4 | P27487 | 2/20 | 0.55 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.55 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 8/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | GNPAT | O15228 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616850 | 1.00 | DPP8 (0.55) | DPP8DPP7DPP4DPP9MME | |
| SCHEMBL29476460 | 0.94 | DPP8 (0.60) | DPP8DPP7DPP4DPP9MME | |
| SCHEMBL16862515 | 0.87 | FOLH1 (0.49) | DPP8DPP7DPP4DPP9NOD1 | |
| SCHEMBL16862514 | 0.87 | FOLH1 (0.49) | DPP8DPP7DPP4DPP9NOD1 | |
| SCHEMBL8492399 | 0.84 | DPP4 (0.51) | DPP8DPP7DPP4DPP9MME | |
| SCHEMBL30590545 | 0.84 | FOLH1 (0.50) | DPP8DPP4DPP9NOD1BACE1 | |
| SCHEMBL30844356 | 0.82 | BACE1 (0.46) | DPP8DPP7DPP4DPP9NOD1 | |
| SCHEMBL24642917 | 0.82 | DPP4 (0.48) | DPP8DPP7DPP4DPP9MME | |
| SCHEMBL29392005 | 0.81 | FOLH1 (0.47) | DPP8DPP7DPP4DPP9NOD1 | |
| SCHEMBL30148936 | 0.81 | MME (0.46) | DPP8DPP7DPP4DPP9MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839155-B1 | CYSTEINE PROTEASE INHIBITORS FOR USE IN TREATMENT OF IgE MEDIATED ALLERGIC DISEASES | MEDIVIR UK LTD (GB) | 2004-10-13 | — | — | EP | disclosed |
| US-20030092067-A1 | Substrates and inhibitors of proteolytic enzymes | PEPTIDE THERAPEUTICS LIMITED | 2003-05-15 | — | — | US | disclosed |
| US-6528275-B1 | Screening for cleavage using combinatorial fluorescence resonance energy transfer (FRET) compounds of given formula; can use to accelerate drug discovery process | PEPTIDE THERAPEUTICS LIMITED (GB) | 2003-03-04 | — | — | US | disclosed |
| EP-0906333-B1 | SUBSTRATES AND INHIBITORS OF PROTEOLYTIC ENZYMES | MEDIVIR UK LTD (GB) | 2001-07-25 | — | — | EP | disclosed |
| US-6034066-A | ANTIALLERGENS | PEPTIDE THERAPEUTICS LIMITED (GB) | 2000-03-07 | — | — | US | disclosed |
| EP-0906333-A2 | SUBSTRATES AND INHIBITORS OF PROTEOLYTIC ENZYMES | PEPTIDE THERAPEUTICS LIMITED (GB) | 1999-04-07 | — | — | EP | disclosed |
| EP-0839155-A1 | CYSTEINE PROTEASE INHIBITORS FOR USE IN TREATMENT OF IgE MEDIATED ALLERGIC DISEASES | PEPTIDE THERAPEUTICS LIMITED (GB) | 1998-05-06 | — | — | EP | disclosed |
| WO-1997040065-A2 | SUBSTRATES AND INHIBITORS OF PROTEOLYTIC ENZYMES | PEPTIDE THERAPEUTICS LIMITED (GB) | 1997-10-30 | — | — | WO | disclosed |
| WO-1997004004-A1 | CYSTEINE PROTEASE INHIBITORS FOR USE IN TREATMENT OF IgE MEDIATED ALLERGIC DISEASES | PEPTIDE THERAPEUTICS LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |