SCHEMBL6678338

SCHEMBL6678338

COc1ccc(Oc2ncc(S(=O)(=O)Nc3ccc(Cl)c(O[C@@H]4CCN(C)C4)c3)cc2Br)cc1

nearest known ligand 0.62

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 13/20 0.62
ERBB2 P04626 1/20 0.41
EPHA2 P29317 1/20 0.41
KDR P35968 1/20 0.41
EPHB4 P54760 1/20 0.41
SCN1A P35498 2/20 0.41
SCN8A Q9UQD0 2/20 0.41
HPGD P15428 1/20 0.41
S100A9 P06702 2/20 0.40
HTR2C P28335 1/20 0.37
HTR2B P41595 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6678344 1.00 UTS2R (0.62) UTS2RERBB2EPHA2KDREPHB4
SCHEMBL6675717 0.93 UTS2R (0.64) UTS2RERBB2EPHA2KDREPHB4
SCHEMBL6675708 0.93 UTS2R (0.64) UTS2RERBB2EPHA2KDREPHB4
SCHEMBL6679727 0.93 UTS2R (0.58) UTS2RERBB2EPHA2KDREPHB4
SCHEMBL6679730 0.93 UTS2R (0.58) UTS2RERBB2EPHA2KDREPHB4
SCHEMBL6674000 0.91 UTS2R (0.58) UTS2RERBB2EPHA2KDREPHB4
SCHEMBL6674005 0.91 UTS2R (0.58) UTS2RERBB2EPHA2KDREPHB4
SCHEMBL6676981 0.90 UTS2R (0.57) UTS2RERBB2EPHA2KDREPHB4
SCHEMBL6676988 0.90 UTS2R (0.57) UTS2RERBB2EPHA2KDREPHB4
SCHEMBL6825135 0.89 UTS2R (0.63) UTS2RS100A9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043463-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed