Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.49 |
| ▸ | CASP6 | P55212 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968611 | 0.84 | G6PD (0.59) | KMT2AMEN1SCN2ANR1H3ESR1 | |
| SCHEMBL11808285 | 0.84 | ESR1 (0.72) | KMT2AMEN1SCN2ANR1H3ESR1 | |
| SCHEMBL10915309 | 0.83 | CYP3A4 (0.60) | KMT2AMEN1SCN2ANR1H3ESR1 | |
| SCHEMBL30758650 | 0.81 | KMT2A (0.76) | KMT2AMEN1SCN2ANR1H3NR1H2 | |
| SCHEMBL29168849 | 0.81 | KMT2A (0.76) | KMT2AMEN1SCN2ANR1H3NR1H2 | |
| SCHEMBL28665183 | 0.80 | ESR1 (0.56) | KMT2AMEN1NR1H3ESR1GRM1 | |
| SCHEMBL6676243 | 0.79 | NR1H3 (0.57) | KMT2AMEN1SCN2ANR1H3ESR1 | |
| SCHEMBL7451753 | 0.79 | NPC1 (0.49) | SCN2ANR1H3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16592564 | 0.78 | RECQL (0.62) | KMT2AMEN1SCN2ANR1H3ESR1 | |
| SCHEMBL30758606 | 0.78 | RECQL (0.62) | KMT2AMEN1SCN2ANR1H3ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |