Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | SMO | Q99835 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7755234 | 0.96 | MAPK14 (0.92) | MAPK14TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL6782336 | 0.88 | MAPK14 (1.00) | MAPK14TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL6781511 | 0.88 | MAPK14 (1.00) | MAPK14TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL6677756 | 0.88 | MAPK14 (1.00) | MAPK14TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL6678101 | 0.88 | MAPK14 (1.00) | MAPK14TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL27527556 | 0.85 | MAPK14 (0.75) | MAPK14TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL2980389 | 0.81 | MAPK14 (0.86) | MAPK14TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL6477379 | 0.80 | MAPK14 (0.85) | MAPK14TP53ALDH1A1KDM4ERAF1 | |
| SCHEMBL6477643 | 0.80 | MAPK14 (0.85) | MAPK14TP53ALDH1A1KDM4ERAF1 | |
| SCHEMBL6476701 | 0.78 | MAPK14 (0.79) | MAPK14TP53ALDH1A1KDM4ERAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188389-C | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRA ZENECA LTD (SE) | 2005-02-09 | — | — | CN | disclosed |
| EP-1077930-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-10 | — | — | EP | disclosed |
| US-6465455-B1 | TUMOUR NECROSIS FACTOR AND INTERLEUKIN FAMILY INHIBITORS; INHIBITION OF ENZYME P38 KINASE; INFLAMMATION, IMMUNO-REGULATION, ALLERGIES | ASTRAZENECA AB (SE) | 2002-10-15 | — | — | US | disclosed |