Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 1.00 |
| ▸ | EGFR | P00533 | 2/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6781511 | 0.88 | MAPK14 (1.00) | MAPK14ALDH1A1MAPTTP53HPGD | |
| SCHEMBL6782336 | 0.88 | MAPK14 (1.00) | MAPK14ALDH1A1MAPTTP53HPGD | |
| SCHEMBL6679437 | 0.88 | MAPK14 (1.00) | MAPK14EGFRALDH1A1MAPTTP53 | |
| SCHEMBL6677756 | 0.88 | MAPK14 (1.00) | MAPK14EGFRALDH1A1MAPTTP53 | |
| SCHEMBL6676301 | 0.87 | MAPK14 (0.77) | MAPK14EGFRPDE4DALDH1A1MAPT | |
| SCHEMBL7755234 | 0.86 | MAPK14 (0.92) | MAPK14EGFRALDH1A1MAPTTP53 | |
| SCHEMBL27527556 | 0.85 | MAPK14 (0.75) | MAPK14EGFRALDH1A1MAPTTP53 | |
| SCHEMBL6682097 | 0.84 | MAPK14 (0.73) | MAPK14EGFRPDE4DALDH1A1MAPT | |
| SCHEMBL6676839 | 0.82 | MAPK14 (0.70) | MAPK14PDE4DALDH1A1MAPTHPGD | |
| SCHEMBL6477643 | 0.82 | MAPK14 (0.85) | MAPK14ALDH1A1MAPTTP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188389-C | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRA ZENECA LTD (SE) | 2005-02-09 | — | — | CN | claimed |
| EP-1077930-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-10 | — | — | EP | claimed |
| US-6465455-B1 | TUMOUR NECROSIS FACTOR AND INTERLEUKIN FAMILY INHIBITORS; INHIBITION OF ENZYME P38 KINASE; INFLAMMATION, IMMUNO-REGULATION, ALLERGIES | ASTRAZENECA AB (SE) | 2002-10-15 | — | — | US | claimed |
| CN-1359371-A | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRA ZENECA LTD (SE) | 2002-07-17 | — | — | CN | claimed |
| EP-1077930-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | claimed |
| WO-1999059960-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | claimed |
| CN-1188389-C | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRA ZENECA LTD (SE) | 2005-02-09 | — | — | CN | disclosed |
| EP-1077930-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-10 | — | — | EP | disclosed |
| US-6465455-B1 | TUMOUR NECROSIS FACTOR AND INTERLEUKIN FAMILY INHIBITORS; INHIBITION OF ENZYME P38 KINASE; INFLAMMATION, IMMUNO-REGULATION, ALLERGIES | ASTRAZENECA AB (SE) | 2002-10-15 | — | — | US | disclosed |
| CN-1359371-A | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRA ZENECA LTD (SE) | 2002-07-17 | — | — | CN | disclosed |
| EP-1077930-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059960-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |