Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 3/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGAV | P06756 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | MGAT2 | Q10469 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487340 | 0.92 | ITGB1 (0.45) | ITGB1ITGA5TP53S1PR1S1PR3 | |
| SCHEMBL6487913 | 0.89 | CHRNB2 (0.43) | ITGB1ITGA5TP53ITGB3ITGAV | |
| SCHEMBL6501432 | 0.89 | ITGB1 (0.42) | ITGB1ITGA5TP53S1PR1S1PR3 | |
| SCHEMBL6498885 | 0.89 | PPARG (0.37) | ITGB1ITGA5TP53ITGB3ITGAV | |
| SCHEMBL6531977 | 0.87 | TP53 (0.40) | TP53MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL6503188 | 0.86 | NPC1 (0.45) | TP53MAPTKDM4EHTTDHODH | |
| SCHEMBL6491900 | 0.85 | SMN1; SMN2 (0.58) | TP53MAPTKDM4EHPGDHTT | |
| SCHEMBL6501730 | 0.84 | GAA (0.40) | TP53KDM4EHPGDHSD17B10DHODH | |
| SCHEMBL6490709 | 0.83 | CHRNB2 (0.45) | ITGB1ITGA5TP53MAPTKDM4E | |
| SCHEMBL6500761 | 0.82 | ITGB1 (0.43) | ITGB1ITGA5TP53MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |