Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674323 | 0.90 | PDGFRB (0.46) | SMN1; SMN2HTTKDM4ELMNAPOLB | |
| SCHEMBL3677990 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2HTTKDM4ELMNAPOLB | |
| SCHEMBL3667468 | 0.85 | PARP1 (0.45) | SMN1; SMN2HTTKDM4ELMNAPOLB | |
| SCHEMBL3667669 | 0.84 | AXL (0.47) | HTTTDP1GRM5SLK | |
| SCHEMBL6689989 | 0.83 | KDM4E (0.43) | SMN1; SMN2HTTKDM4ELMNAPOLB | |
| SCHEMBL3665777 | 0.81 | CCNE1 (0.40) | SMN1; SMN2HTTKDM4ELMNAL3MBTL1 | |
| SCHEMBL3667347 | 0.81 | MAPK14 (0.42) | SMN1; SMN2HTTKDM4EJAK2JAK3 | |
| SCHEMBL3666596 | 0.81 | CYP2A6 (0.37) | SMN1; SMN2HTTLMNAL3MBTL1NPC1 | |
| SCHEMBL3672899 | 0.81 | CYP2A6 (0.40) | SMN1; SMN2HTTLMNAL3MBTL1NPC1 | |
| SCHEMBL2918049 | 0.79 | GRIA1 (0.47) | SMN1; SMN2HTTKDM4ELMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |