Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2918049 | 0.83 | GRIA1 (0.47) | KDM4ESMN1; SMN2HTTLMNAL3MBTL1 | |
| SCHEMBL6686812 | 0.83 | GRIA1 (0.47) | KDM4ESMN1; SMN2HTTLMNAL3MBTL1 | |
| Water SCHEMBL4777584 | 0.83 | GRIA1 (0.47) | KDM4ESMN1; SMN2HTTLMNAL3MBTL1 | |
| SCHEMBL6679862 | 0.83 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2HTTLMNAPOLB | |
| SCHEMBL2762970 | 0.82 | MCL1 (0.50) | KDM4ESMN1; SMN2HTTLMNAL3MBTL1 | |
| SCHEMBL6698453 | 0.80 | GRIA1 (0.47) | KDM4ESMN1; SMN2HTTLMNAL3MBTL1 | |
| SCHEMBL1882884 | 0.80 | GRIA1 (0.47) | KDM4ESMN1; SMN2HTTLMNAL3MBTL1 | |
| SCHEMBL3667719 | 0.79 | HTT (0.49) | KDM4EHTTGAANPC1RAB9A | |
| SCHEMBL6674323 | 0.79 | PDGFRB (0.46) | KDM4ESMN1; SMN2HTTLMNAPOLB | |
| SCHEMBL6691807 | 0.78 | PTGS2 (0.43) | GRIA1GRIA3PDE4DCBFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |