Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NQO2 | P16083 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891344 | 0.83 | MAPT (0.54) | MEN1KMT2ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL6682212 | 0.83 | NQO2 (0.53) | PTPN1MEN1KMT2ASMN1; SMN2NQO2 | |
| SCHEMBL30408678 | 0.83 | NQO2 (0.53) | PTPN1MEN1KMT2ASMN1; SMN2NQO2 | |
| SCHEMBL29814877 | 0.82 | MTNR1A (0.59) | MEN1KMT2ASMN1; SMN2NQO2MTNR1A | |
| SCHEMBL5981610 | 0.81 | MTNR1A (0.48) | NQO2MTNR1AMTNR1B | |
| SCHEMBL3152901 | 0.81 | MTNR1A (0.48) | SMN1; SMN2NQO2MTNR1AMTNR1BNPC1 | |
| SCHEMBL6675910 | 0.81 | MTNR1A (0.48) | SMN1; SMN2NQO2MTNR1AMTNR1BNPC1 | |
| SCHEMBL7261722 | 0.80 | MTNR1A (0.50) | MEN1KMT2ASMN1; SMN2NQO2MTNR1A | |
| SCHEMBL7239004 | 0.79 | NQO2 (0.41) | FAAHMEN1KMT2ANQO2MTNR1A | |
| SCHEMBL17934172 | 0.78 | SMN1; SMN2 (0.51) | MEN1KMT2ASMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |