Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 3/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | UNG | P13051 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6680252 | 1.00 | HSP90AA1 (0.38) | HSP90AA1CCR6P4HBMITFTTR | |
| SCHEMBL6678554 | 1.00 | HSP90AA1 (0.38) | HSP90AA1CCR6P4HBMITFTTR | |
| Hydrochloric Acid SCHEMBL6721153 | 0.99 | HSP90AA1 (0.40) | HSP90AA1CCR6P4HBMITFTTR | |
| Hydrochloric Acid SCHEMBL6721152 | 0.99 | HSP90AA1 (0.40) | HSP90AA1CCR6P4HBMITFTTR | |
| SCHEMBL6678900 | 0.90 | P4HB (0.42) | HSP90AA1CCR6P4HBMITFHSD17B1 | |
| SCHEMBL6678902 | 0.90 | P4HB (0.42) | HSP90AA1CCR6P4HBMITFHSD17B1 | |
| SCHEMBL6679108 | 0.90 | P4HB (0.42) | HSP90AA1CCR6P4HBMITFHSD17B1 | |
| Hydrochloric Acid SCHEMBL6716303 | 0.89 | HSP90AA1 (0.42) | HSP90AA1CCR6P4HBMITFHSD17B1 | |
| Hydrochloric Acid SCHEMBL6716562 | 0.89 | HSP90AA1 (0.42) | HSP90AA1CCR6P4HBMITFHSD17B1 | |
| Hydrochloric Acid SCHEMBL6716297 | 0.89 | HSP90AA1 (0.42) | HSP90AA1CCR6P4HBMITFHSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246793-B1 | SUBSTITUTED AMINOMETHYL-PHENYL-CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-11-10 | — | — | EP | disclosed |
| US-6673794-B2 | ANALGESICS, INCOTINENCE, SKIN DISORDERS, ANTIINFLAMMATORY AGENTS | GRUENENTHAL GMBH (DE) | 2004-01-06 | — | — | US | disclosed |
| US-20030069288-A1 | Substituted aminomethyl-phenyl-cyclohexane derivatives | GRUENETHAL GMBH (DE) | 2003-04-10 | — | — | US | disclosed |
| EP-1246793-A2 | SUBSTITUTED AMINOMETHYL-PHENYL-CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049654-A2 | SUBSTITUTED AMINOMETHYL-PHENYL-CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2001-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069288-A1 | Substituted aminomethyl-phenyl-cyclohexane derivatives | PTGER1, CYP2E1, HRH2 | HSP90AA1 1652/4885CCR6 1317/4885P4HB 2142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.