Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | FPR1 | P21462 | 1/20 | 0.45 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854778 | 0.85 | ALDH1A1 (0.55) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL9224380 | 0.84 | ALDH1A1 (0.57) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL30872632 | 0.83 | ALDH1A1 (0.53) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL30872649 | 0.83 | ALDH1A1 (0.53) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL19132556 | 0.83 | ALDH1A1 (0.53) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL28626914 | 0.82 | ALDH1A1 (0.52) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL28421573 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL28416316 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL28420241 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL28415424 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KMT2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-B1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIV SAARLAND (DE) | 2016-01-27 | — | — | EP | disclosed |
| US-8912186-B2 | Allosteric protein kinase modulators | UNIVERSITAET DES SAARLANDES (DE) | 2014-12-16 | — | — | US | disclosed |
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2012-02-23 | — | — | US | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |
| EP-2177510-A1 | Allosteric protein kinase modulators | Universität des Saarlandes (DE) | 2010-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | AURKC, AURKA, AURKB | ALDH1A1 4784/4885KMT2A 1777/4885SMN1; SMN2 4389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.