SCHEMBL6682667

SCHEMBL6682667

NCCC(O)(Cc1ccccc1)c1cccs1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.39
HIF1A Q16665 1/20 0.39
TAAR1 Q96RJ0 3/20 0.38
SLC6A2 P23975 1/20 0.38
MMP1 P03956 1/20 0.36
MMP9 P14780 1/20 0.36
MMP13 P45452 1/20 0.36
CHRM2 P08172 4/20 0.35
CHRM1 P11229 4/20 0.35
CHRM3 P20309 4/20 0.35
KIF11 P52732 2/20 0.35
LMNA P02545 1/20 0.35
FDPS P14324 1/20 0.34
RAB9A P51151 2/20 0.34
HPGD P15428 2/20 0.34
NPC1 O15118 1/20 0.34
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5177097 0.84 CYP1A2 (0.41) CYP1A2CYP2C9CYP2C19SMN1; SMN2TAAR1
SCHEMBL6682429 0.79 ESR1 (0.40) CYP2C9CYP2C19TAAR1CHRM2CHRM1
SCHEMBL8761330 0.71 SLC6A2 (0.53) CYP1A2CYP2C9CYP2C19SMN1; SMN2HIF1A
SCHEMBL3225215 0.71 ESR1 (0.39) CYP2C9CYP2C19TAAR1CHRM2CHRM1
SCHEMBL1234779 0.71 SMN1; SMN2 (0.49) CYP1A2CYP2C9CYP2C19SMN1; SMN2HIF1A
Hydrochloric Acid SCHEMBL9482275 0.70 SLC6A2 (0.52) CYP1A2CYP2C9CYP2C19SMN1; SMN2HIF1A
SCHEMBL1234777 0.70 SMN1; SMN2 (0.43) CYP1A2CYP2C9CYP2C19SMN1; SMN2HIF1A
SCHEMBL8760163 0.69 CYP3A4 (0.67) CYP1A2CYP2C9CYP2C19SMN1; SMN2HIF1A
SCHEMBL4552971 0.68 TAAR1 (0.52) CYP1A2CYP2C9CYP2C19SMN1; SMN2HIF1A
SCHEMBL158683 0.67 ESR1 (0.51) CYP2C9CYP2C19CHRM2CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1476439-A1 PREPARATION OF N-METHYL-3-HYDROXY- 3-(2-THIENYL)PROPYLAMINE VIA NOVEL THIOPHENE DERIVATIVES CONTAINING CARBAMATE GROUPS AS INTERMEDIATES Degussa AG (DE) 2004-11-17 EP disclosed
WO-2003070720-A1 PREPARATION OF N-METHYL-3-HYDROXY- 3-(2-THIENYL)PROPYLAMINE VIA NOVEL THIOPHENE DERIVATIVES CONTAINING CARBAMATE GROUPS AS INTERMEDIATES DEGUSSA AG (DE) 2003-08-28 WO disclosed