Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16692506 | 0.80 | TNF (0.50) | TNFHDAC7PDE4APDE4BPDE4C | |
| SCHEMBL19053750 | 0.78 | TNF (0.44) | TNFHDAC7PDE4APDE4BPDE4C | |
| SCHEMBL28076404 | 0.77 | HDAC7 (0.42) | TNFHDAC7ACP3 | |
| SCHEMBL16679673 | 0.75 | TNF (0.47) | TNFALDH1A1HDAC7HSD17B10L3MBTL1 | |
| SCHEMBL8914085 | 0.74 | MEN1 (0.45) | TNFALDH1A1HDAC7HSD17B10TYR | |
| SCHEMBL28076631 | 0.74 | TNF (0.55) | TNFHDAC7PDE4APDE4BPDE4C | |
| SCHEMBL16679652 | 0.74 | TNF (0.46) | TNFALDH1A1HDAC7HSD17B10L3MBTL1 | |
| SCHEMBL16959101 | 0.71 | ACP3 (0.39) | ALDH1A1L3MBTL1ACP3 | |
| SCHEMBL16690783 | 0.69 | UTS2R (0.53) | TNFHDAC7PDE4APDE4BPDE4C | |
| SCHEMBL10318765 | 0.69 | UTS2R (0.53) | TNFHDAC7PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004071445-A2 | 2-(AMINOMETHYL)ARYLAMIDE ANALGESICS | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2004-08-26 | — | — | WO | disclosed |