SCHEMBL6683751

SCHEMBL6683751

CC(C)(C(=O)NC1[C@@H]2CC3C[C@H]1CC(O)(C3)C2)c1ccccc1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 19/20 0.77
HSD11B2 P80365 6/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12585728 1.00 HSD11B1 (0.77) HSD11B1HSD11B2
SCHEMBL6683755 1.00 HSD11B1 (0.77) HSD11B1HSD11B2
SCHEMBL6683748 1.00 HSD11B1 (0.77) HSD11B1HSD11B2
SCHEMBL12585721 1.00 HSD11B1 (0.77) HSD11B1HSD11B2
SCHEMBL4826240 1.00 HSD11B1 (0.77) HSD11B1HSD11B2
SCHEMBL6142628 0.87 HSD11B1 (0.80) HSD11B1HSD11B2
SCHEMBL12586208 0.87 HSD11B1 (1.00) HSD11B1HSD11B2
SCHEMBL12586211 0.87 HSD11B1 (1.00) HSD11B1HSD11B2
SCHEMBL6142615 0.87 HSD11B1 (1.00) HSD11B1HSD11B2
SCHEMBL4826225 0.87 HSD11B1 (0.80) HSD11B1HSD11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004056744-A1 ADAMANTYL ACETAMIDES AS HYDROXYSTEROID DEHYDROGENASE INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2004-07-08 WO disclosed