Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27946424 | 0.88 | TSHR (0.61) | TSHRALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL2636255 | 0.79 | KDM4E (0.46) | TSHRALDH1A1TP53MEN1KMT2A | |
| SCHEMBL29387070 | 0.79 | TSHR (0.69) | TSHRALDH1A1HSD17B10MAPK1TP53 | |
| SCHEMBL180024 | 0.79 | TSHR (0.69) | TSHRALDH1A1HSD17B10MAPK1TP53 | |
| Ammonia Solution, Strong SCHEMBL10715942 | 0.77 | TSHR (0.67) | TSHRALDH1A1HSD17B10MAPK1NPSR1 | |
| SCHEMBL6684555 | 0.77 | P2RX7 (0.45) | TSHRALDH1A1HSD17B10MAPK1TP53 | |
| SCHEMBL27696491 | 0.77 | TSHR (0.53) | TSHRALDH1A1HSD17B10MAPK1NPSR1 | |
| SCHEMBL1479235 | 0.77 | TSHR (0.61) | TSHRALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL6014497 | 0.76 | TSHR (0.49) | TSHRALDH1A1HSD17B10MAPK1NPSR1 | |
| SCHEMBL31126854 | 0.75 | TSHR (0.62) | TSHRALDH1A1HSD17B10NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052280-A2 | ANTI-ANGIOGENIC COMPOUNDS AND THEIR USE IN CANCER TREATMENT | IMCLONE SYSTEMS INCORPORATED (US) | 2004-06-24 | — | — | WO | disclosed |