Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14299159 | 0.80 | CYP2A6 (0.42) | DYRK1AAXLMKNK1MKNK2KDM4E | |
| SCHEMBL6644638 | 0.77 | DYRK1A (0.44) | DYRK1AAXLMKNK1MKNK2KDM4E | |
| SCHEMBL21782770 | 0.77 | DYRK1A (0.37) | DYRK1AKDM4ECYP2A6CCR1CCR5 | |
| SCHEMBL22032490 | 0.73 | DYRK1A (0.41) | DYRK1AAXLMKNK1MKNK2KDM4E | |
| SCHEMBL6645435 | 0.73 | DYRK1A (0.38) | DYRK1AKDM4ECYP2A6MAPTHTT | |
| SCHEMBL18819885 | 0.72 | CYP2A6 (0.42) | DYRK1AAXLMKNK1MKNK2KDM4E | |
| SCHEMBL198689 | 0.71 | ALDH1A1 (0.46) | KDM4EPOLBMAPTHTTNPC1 | |
| SCHEMBL25841258 | 0.71 | DYRK1A (0.42) | DYRK1AAXLMKNK1MKNK2ADORA2A | |
| SCHEMBL31484406 | 0.70 | DYRK1A (0.39) | DYRK1AAXLMKNK1MKNK2KDM4E | |
| SCHEMBL18876005 | 0.69 | DYRK1A (0.40) | DYRK1AAXLMKNK1MKNK2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409491-A2 | THIENOPYRIMIDINE-BASED INHIBITORS OF THE SRC FAMILY | Board of Regents, The University of Texas System (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002057271-A2 | THIENOPYRIMIDINE-BASED INHIBITORS OF THE SRC FAMILY | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-07-25 | — | — | WO | disclosed |