Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13804176 | 0.78 | CYP1A2 (0.54) | CHEK1CYP1A2CYP2A6EGFRNPC1 | |
| Hydrochloric Acid SCHEMBL7398907 | 0.76 | CYP1A2 (0.52) | CHEK1CYP1A2CYP2A6EGFRNPC1 | |
| SCHEMBL12915410 | 0.74 | CYP1A2 (0.50) | CHEK1CYP1A2CYP2A6EGFRNPC1 | |
| SCHEMBL1922139 | 0.74 | PDGFRB (0.56) | CHEK1CYP1A2CYP2A6NPC1RAB9A | |
| SCHEMBL25242404 | 0.74 | PDPK1 (0.54) | CHEK1CYP1A2CYP2A6EGFRNPC1 | |
| SCHEMBL3662977 | 0.74 | CHEK1 (0.49) | CHEK1CYP1A2CYP2A6EGFRNPC1 | |
| SCHEMBL14599973 | 0.73 | CYP1A2 (0.48) | CHEK1CYP1A2CYP2A6EGFRNPC1 | |
| SCHEMBL14185051 | 0.73 | CYP1A2 (0.48) | CHEK1CYP1A2CYP2A6EGFRNPC1 | |
| SCHEMBL28512102 | 0.73 | USP30 (0.49) | CHEK1CYP1A2CYP2A6EGFRNOTUM | |
| SCHEMBL7748723 | 0.73 | CYP1A2 (0.48) | CHEK1CYP1A2CYP2A6EGFRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |