Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.54 |
| ▸ | CDK4 | P11802 | 12/20 | 0.54 |
| ▸ | CDK9 | P50750 | 8/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.54 |
| ▸ | CDK1 | P06493 | 5/20 | 0.54 |
| ▸ | CDK7 | P50613 | 5/20 | 0.54 |
| ▸ | AURKA | O14965 | 4/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.54 |
| ▸ | CCNH | P51946 | 3/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | ABL2 | P42684 | 1/20 | 0.54 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801897 | 0.88 | CDK2 (0.69) | CDK2CDK4CDK9CCNT1CDK1 | |
| SCHEMBL4797469 | 0.77 | CDK2 (0.70) | CDK2CDK4CDK9CCNT1CDK1 | |
| SCHEMBL6675610 | 0.77 | CDK2 (0.52) | CDK2CDK4CDK9CCNT1CDK1 | |
| SCHEMBL6675388 | 0.77 | CDK2 (0.54) | CDK2CDK4CDK9CCNT1CDK1 | |
| SCHEMBL5180395 | 0.75 | CDK2 (0.60) | CDK2CDK4CDK9CCNT1CDK1 | |
| SCHEMBL2074426 | 0.72 | CDK2 (0.71) | CDK2CDK4CDK9CCNT1CDK1 | |
| SCHEMBL7089036 | 0.71 | CDK2 (0.78) | CDK2CDK4CDK9CCNT1CDK1 | |
| SCHEMBL4613774 | 0.71 | CDK2 (0.80) | CDK2CDK4CDK9CCNT1CDK1 | |
| SCHEMBL6684173 | 0.70 | CDK2 (0.63) | CDK2CDK4CDK9CCNT1CDK1 | |
| SCHEMBL29644994 | 0.70 | CDK2 (1.00) | CDK2CDK4CDK9CCNT1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430051-A1 | N-(4-(4-METHYLTHIAZOL-5-YL)PYRIMIDIN-2-YL)-N-PHENYLAMINES AS ANTIPROLIFERATIVE COMPOUNDS | Cyclacel Limited (GB) | 2004-06-23 | — | — | EP | claimed |
| WO-2003029248-A1 | N-(4-(4-METHYLTHIAZOL-5-YL) PYRIMIDIN-2-YL) -N-PHENYLAMINES AS ANTIPROLIFERATIVE COMPOUNDS | CYCLACEL LIMITED (GB) | 2003-04-10 | — | — | WO | claimed |