⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL94890 | 0.90 | — | — | |
| SCHEMBL1008881 | 0.87 | TSHR (0.75) | — | |
| SCHEMBL821656 | 0.87 | TSHR (0.75) | — | |
| SCHEMBL1006395 | 0.87 | TSHR (0.75) | — | |
| SCHEMBL95801 | 0.87 | — | — | |
| SCHEMBL1008155 | 0.87 | TSHR (0.75) | — | |
| SCHEMBL1006840 | 0.87 | TSHR (0.75) | — | |
| SCHEMBL95166 | 0.87 | TSHR (0.75) | — | |
| SCHEMBL1007211 | 0.87 | TSHR (0.75) | — | |
| SCHEMBL1006545 | 0.87 | TSHR (0.75) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2005 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118284669-A | Asphalt composition comprising asphaltenes and epoxy-functionalized ethylene copolymers | 陶氏环球技术有限责任公司 | 2024-07-02 | — | — | CN | claimed |
| US-20220402897-A1 | CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2022-12-22 | — | — | US | claimed |
| CN-112839714-A | Chromen-4-one derivatives for the treatment and prevention of hepatitis B virus diseases | 豪夫迈·罗氏有限公司 | 2021-05-25 | — | — | CN | claimed |
| US-10968198-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2021-04-06 | — | — | US | claimed |
| CN-107820496-B | Tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prevention of hepatitis B virus infections | 豪夫迈·罗氏有限公司 | 2020-11-03 | — | — | CN | claimed |
| CN-107624113-B | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2020-10-23 | — | — | CN | claimed |
| EP-3267794-B1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2020-09-09 | — | — | EP | claimed |
| CN-111247415-A | Refractive index matching formulation | 生命科技股份有限公司 | 2020-06-05 | — | — | CN | claimed |
| WO-2020079106-A1 | CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-04-23 | — | — | WO | claimed |
| US-20190276425-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2019-09-12 | — | — | US | claimed |
| EP-0712388-A1 | USE OF PHENOLS AND PHENOL DERIVATES AS MEDICAMENTS WITH FIBRINOGEN-REDUCING EFFECT | Roche Diagnostics GmbH (DE) | 1996-05-22 | — | — | EP | claimed |
| EP-0676396-A1 | Tetrazolylphenyl pivalate derivatives and medicinal composition containing the same as effective component | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1995-10-11 | — | — | EP | claimed |
| US-5430130-A | Photosensitive polyfunctional aromatic diazo compounds useful in photosensitive compositions | TOYO GOSEI KOGYO CO., LTD. (JP) | 1995-07-04 | — | — | US | claimed |
| US-5395742-A | IMAGEWISE EXPOSURE OF A PHOTOGRAPHIC MATERIAL TO LIGHT | FUJI PHOTO FILM CO., LTD. (JP) | 1995-03-07 | — | — | US | claimed |
| WO-1995005358-A1 | USE OF PHENOLS AND PHENOL DERIVATES AS MEDICAMENTS WITH FIBRINOGEN-REDUCING EFFECT | BOEHRINGER MANNHEIM GMBH (DE) | 1995-02-23 | — | — | WO | claimed |
| EP-0626374-A2 | A diaminostilbene series compound and a method for forming an image using the same | FUJI PHOTO FILM CO., LTD. (JP) | 1994-11-30 | — | — | EP | claimed |
| EP-0454501-A2 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | Sankyo Company Limited (JP) | 1991-10-30 | — | — | EP | claimed |
| EP-0123902-B1 | PROCEDURE FOR THE DETERMINATION OF PEROXIDASE ACTIVITY BY END DILUTION TITRATION AND MEANS FOR ITS REALIZATION | Byk-Sangtec Diagnostica GmbH & Co. KG (DE) | 1991-09-18 | — | — | EP | claimed |
| EP-0036730-B1 | BICYCLOOCTANE DERIVATIVES, PROCESSES FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, THEIR USE AS PHARMACEUTICALS AND PRECURSORS THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-01-02 | — | — | EP | claimed |
| EP-0123902-A2 | Procedure for the determination of peroxidase activity by end dilution titration and means for its realization | Byk-Sangtec Diagnostica GmbH & Co. KG (DE) | 1984-11-07 | — | — | EP | claimed |