Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.44 |
| ▸ | SRC | P12931 | 10/20 | 0.44 |
| ▸ | TEK | Q02763 | 8/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FRK | P42685 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430375 | 0.86 | LCK (0.61) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL5822930 | 0.74 | SRC (0.51) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL5823668 | 0.72 | SRC (0.57) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL5822928 | 0.71 | SRC (0.65) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL5823664 | 0.69 | LCK (0.71) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL6692919 | 0.68 | SRC (0.45) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL5801721 | 0.68 | LCK (0.66) | LCKSRCTEKKDRLIMK1 | |
| SCHEMBL5821051 | 0.68 | SRC (0.52) | LCKSRCTEKKDRABL1 | |
| SCHEMBL5804660 | 0.67 | SRC (0.61) | LCKSRCTEKKDRABL1 | |
| SCHEMBL6431127 | 0.66 | LCK (0.79) | LCKSRCTEKKDRLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212327-B8 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2004-02-25 | — | — | EP | disclosed |
| EP-1212327-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019829-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |