Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 3/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | LYN | P07948 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.47 |
| ▸ | TNF | P01375 | 4/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.47 |
| ▸ | HCK | P08631 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | MUSK | O15146 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5989034 | 0.92 | MAPK9 (0.55) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL6686496 | 0.87 | MAPK9 (0.52) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL7602984 | 0.86 | MAPK9 (0.68) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL6452416 | 0.85 | MAPK9 (0.51) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL5988430 | 0.84 | MAPK9 (0.51) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL17237755 | 0.83 | MAPK14 (0.67) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL5990657 | 0.83 | MAPK9 (0.46) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL6690499 | 0.82 | MAPK9 (0.48) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL6689391 | 0.81 | MAPK14 (0.43) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL4081890 | 0.81 | ABL1 (0.75) | MAPK9ABL1RAF1LYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427412-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003022273-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |