Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.43 |
| ▸ | TNF | P01375 | 3/20 | 0.43 |
| ▸ | HCK | P08631 | 2/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | MUSK | O15146 | 1/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5989034 | 0.92 | MAPK9 (0.55) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL5990657 | 0.88 | MAPK9 (0.46) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL6452416 | 0.88 | MAPK9 (0.51) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL7602984 | 0.87 | MAPK9 (0.68) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL5988430 | 0.87 | MAPK9 (0.51) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL6685219 | 0.87 | MAPK9 (0.50) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL6690499 | 0.85 | MAPK9 (0.48) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL27556644 | 0.82 | MAPK9 (0.52) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL6689156 | 0.81 | ABL1 (0.60) | MAPK9ABL1RAF1LYNSRC | |
| SCHEMBL5997447 | 0.81 | MAPK9 (0.43) | MAPK9ABL1RAF1LYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002539198-A | — | — | 2002-11-19 | — | — | JP | claimed |
| EP-1165516-A2 | HETEROCYCLIC UREA AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000055139-A2 | HETEROCYCLIC UREA AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | claimed |
| EP-1427412-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003022273-A1 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |