Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.48 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 2/20 | 0.31 |
| ▸ | GABRD | O14764 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21521060 | 0.89 | TSHR (0.46) | TSHRGABRR1GABRR2BLMGABRR3 | |
| SCHEMBL3023206 | 0.89 | TSHR (0.46) | TSHRGABRR1GABRR2BLMGABRR3 | |
| SCHEMBL3023205 | 0.89 | TSHR (0.46) | TSHRGABRR1GABRR2BLMGABRR3 | |
| SCHEMBL3359819 | 0.76 | TSHR (0.48) | TSHRGABRR1GABRR2BLMGABRR3 | |
| SCHEMBL3359822 | 0.76 | TSHR (0.48) | TSHRGABRR1GABRR2BLMGABRR3 | |
| SCHEMBL2467206 | 0.75 | TSHR (0.46) | TSHRGABRR1GABRR2BLMGABRR3 | |
| SCHEMBL2467205 | 0.75 | TSHR (0.46) | TSHRGABRR1GABRR2BLMGABRR3 | |
| Hydrochloric Acid SCHEMBL21001954 | 0.74 | TSHR (0.46) | TSHRGABRR1GABRR2BLMGABRR3 | |
| Hydrochloric Acid SCHEMBL21001952 | 0.74 | TSHR (0.46) | TSHRGABRR1GABRR2BLMGABRR3 | |
| Glycine SCHEMBL5168496 | 0.74 | GLRA1 (0.46) | TSHRGABRR1GABRR2BLMGABRR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074316-A1 | CONFORMATIONALLY CONSTRAINED BACKBONE CYCLIZED PEPTIDE ANALOGS | GILON CHAIM (IL) | 2004-09-02 | — | — | WO | disclosed |
| EP-0804468-A1 | CONFORMATIONALLY CONSTRAINED BACKBONE CYCLIZED PEPTIDE ANALOG | PEPTOR LTD (IL) | 1997-11-05 | — | — | EP | disclosed |
| WO-1995033765-A1 | CONFORMATIONALLY CONSTRAINED BACKBONE CYCLIZED PEPTIDE ANALOG | PEPTOR LTD. (IL) | 1995-12-14 | — | — | WO | disclosed |