Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6683379 | 0.87 | MAPT (0.46) | MAPTBRD4CHRM2CHRM4CHRM5 | |
| SCHEMBL9356317 | 0.87 | CHRM2 (0.47) | KCNH2OPRK1OPRM1OPRD1SIRT1 | |
| SCHEMBL9356325 | 0.87 | CHRM2 (0.47) | KCNH2OPRK1OPRM1OPRD1SIRT1 | |
| SCHEMBL6684412 | 0.82 | CYP3A4 (0.54) | MAPTALDH1A1 | |
| SCHEMBL3162914 | 0.80 | CYP3A4 (0.46) | KCNH2OPRK1OPRM1OPRD1SIRT1 | |
| SCHEMBL8301823 | 0.80 | CYP3A4 (0.46) | KCNH2OPRK1OPRM1OPRD1SIRT1 | |
| SCHEMBL20811168 | 0.77 | CHRM2 (0.55) | MAPTBRD4CHRM2CHRM4CHRM5 | |
| SCHEMBL20797832 | 0.77 | CHRM2 (0.55) | MAPTBRD4CHRM2CHRM4CHRM5 | |
| SCHEMBL26041498 | 0.77 | CYP3A4 (0.55) | MAPTALDH1A1 | |
| SCHEMBL28842221 | 0.76 | KCNH2 (0.47) | KCNH2OPRK1OPRM1OPRD1SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004071454-A2 | SUBSTITUTED AZETIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS INC. (US) | 2004-08-26 | — | — | WO | disclosed |
| WO-2004071454-A2 | SUBSTITUTED AZETIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS INC. (US) | 2004-08-26 | — | — | WO | disclosed |