Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9356317 | 1.00 | CHRM2 (0.47) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL9352596 | 0.87 | FKBP1A (0.49) | KCNH2OPRK1SPHK1 | |
| SCHEMBL9352606 | 0.87 | FKBP1A (0.49) | KCNH2OPRK1SPHK1 | |
| SCHEMBL9352588 | 0.87 | FKBP1A (0.49) | KCNH2OPRK1SPHK1 | |
| SCHEMBL6685344 | 0.87 | MAPT (0.44) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL3162914 | 0.85 | CYP3A4 (0.46) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL8301823 | 0.85 | CYP3A4 (0.46) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL9356296 | 0.85 | CHRM2 (0.50) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL9352549 | 0.85 | CHRM2 (0.50) | CHRM2CHRM4CHRM5KCNH2OPRK1 | |
| SCHEMBL28842221 | 0.85 | KCNH2 (0.47) | KCNH2OPRK1OPRM1OPRD1SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299513-B1 | Azetidine derivatives, compositions and their use | FIDIA GEORGETOWN INST (US) | 1994-10-05 | — | — | EP | disclosed |
| US-4990504-A | Modulate excitatory amino acid receptor system | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1991-02-05 | — | — | US | disclosed |
| US-4946839-A | ALZHEIMER'S DISEASE | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0299513-A1 | Azetidine derivatives, compositions and their use | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1989-01-18 | — | — | EP | disclosed |