Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | HK1 | P19367 | 1/20 | 0.59 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 2/20 | 0.47 |
| ▸ | SORD | Q00796 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7165611 | 0.94 | RAB9A (0.62) | RAB9ANPC1HK1HKDC1HRH4 | |
| SCHEMBL31254441 | 0.83 | RAB9A (0.57) | RAB9ANPC1HK1HKDC1MAPT | |
| SCHEMBL5030785 | 0.83 | RAB9A (0.63) | RAB9ANPC1HK1HKDC1HRH4 | |
| SCHEMBL10854498 | 0.81 | HRH4 (0.59) | RAB9ANPC1HRH4MAPTKDM4E | |
| SCHEMBL1124002 | 0.81 | HPGD (0.60) | RAB9ANPC1HK1HKDC1HRH4 | |
| SCHEMBL1123454 | 0.81 | HPGD (0.60) | RAB9ANPC1HK1HKDC1HRH4 | |
| SCHEMBL15800694 | 0.78 | PLD1 (0.73) | RAB9AMAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL29857922 | 0.78 | PLD1 (0.73) | RAB9AMAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL21353591 | 0.78 | — | — | |
| SCHEMBL11395686 | 0.78 | MAPT (0.68) | RAB9ANPC1HK1HKDC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004034967-A2 | 2,4,6-TRIAMINOPYRIMIDINES FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2004-04-29 | — | — | WO | disclosed |