Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9779981 | 0.82 | RAB9A (0.53) | HDAC6SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL4731965 | 0.77 | GRM4 (0.74) | GRM4HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31164933 | 0.77 | NPC1 (0.56) | HDAC6NPC1RAB9AALDH1A1POLB | |
| SCHEMBL2530324 | 0.76 | GRM4 (1.00) | GRM4HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29496401 | 0.76 | GRM4 (1.00) | GRM4HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4701467 | 0.76 | HDAC6 (0.43) | GRM4HDAC6ALDH1A1TSHRKDR | |
| SCHEMBL3830071 | 0.75 | PTPN1 (0.47) | SMN1; SMN2ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL5115718 | 0.75 | RAB9A (0.69) | SMN1; SMN2NPC1RAB9AALDH1A1POLB | |
| SCHEMBL29516188 | 0.74 | GRM4 (0.68) | GRM4HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL28501806 | 0.74 | GRM4 (0.68) | GRM4HDAC6SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442041-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-04 | — | — | EP | claimed |
| WO-2003040147-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-15 | — | — | WO | claimed |