Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VSIR | Q9H7M9 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9006306 | 0.80 | TDP1 (0.44) | TAAR1KMT2ATDP1 | |
| SCHEMBL4450908 | 0.80 | NR1H2 (0.45) | TAAR1KMT2A | |
| SCHEMBL1723556 | 0.78 | TAAR1 (0.48) | TAAR1MEN1KMT2A | |
| SCHEMBL4081720 | 0.73 | TAAR1 (0.41) | TAAR1MEN1KMT2A | |
| SCHEMBL28356909 | 0.73 | KCNH2 (0.50) | TAAR1KMT2A | |
| SCHEMBL7665114 | 0.71 | TAAR1 (0.42) | SMN1; SMN2TAAR1KMT2A | |
| SCHEMBL19401259 | 0.70 | MEN1 (0.73) | SMN1; SMN2PDCD1CD274LMNAMEN1 | |
| SCHEMBL177039 | 0.70 | MEN1 (0.73) | SMN1; SMN2PDCD1CD274LMNAMEN1 | |
| SCHEMBL725860 | 0.70 | TAAR1 (0.41) | TAAR1KMT2A | |
| SCHEMBL8754414 | 0.70 | NR1H2 (0.47) | TAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483257-A1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | Pfizer Limited (GB) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003076427-A1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2003-09-18 | — | — | WO | disclosed |