SCHEMBL6687600

SCHEMBL6687600

NCc1cccc2ccccc12.N[C@](CCCNC1CCCc2cccnc21)(C(=O)O)C(=O)c1ccc(CNC2CCCc3cccnc32)c2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.41
HDAC6 Q9UBN7 2/20 0.41
CXCR4 P61073 13/20 0.39
ADORA2A P29274 1/20 0.35
SLC40A1 Q9NP59 1/20 0.33
GRM2 Q14416 1/20 0.32
GRM3 Q14832 1/20 0.32
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30
KCNH2 Q12809 1/20 0.30
CCNE1 P24864 1/20 0.30
CDK2 P24941 1/20 0.30
CDK5 Q00535 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6691016 0.83 HDAC1 (0.39) HDAC1HDAC6CXCR4ADORA2ASLC40A1
SCHEMBL7150127 0.83 HDAC1 (0.42) HDAC1HDAC6CXCR4ADORA2ASLC40A1
SCHEMBL7059188 0.82 HDAC1 (0.36) HDAC1HDAC6CXCR4ADORA2ASLC40A1
SCHEMBL6946145 0.77 HDAC1 (0.37) HDAC1HDAC6CXCR4ADORA2ASLC40A1
SCHEMBL6018347 0.76 FOLH1 (0.37) HDAC1HDAC6CXCR4ADORA2ASLC40A1
SCHEMBL6018818 0.76 FOLH1 (0.37) HDAC1HDAC6CXCR4ADORA2ASLC40A1
SCHEMBL6990541 0.76 FOLH1 (0.37) HDAC1HDAC6CXCR4ADORA2ASLC40A1
SCHEMBL6018112 0.76 HDAC1 (0.44) HDAC1HDAC6CXCR4ADORA2ASLC40A1
SCHEMBL7150122 0.74 HDAC1 (0.42) HDAC1HDAC6CXCR4ADORA2ASLC40A1
SCHEMBL6681750 0.74 HDAC1 (0.54) HDAC1HDAC6CXCR4ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1389460-A1 CXCR4-ANTAGONISTIC DRUGS COMPRISING NITROGEN-CONTAINING COMPOUND Kureha Chemical Industry Co., Ltd. (JP) 2004-02-18 EP disclosed