Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6287334 | 1.00 | CA1 (0.57) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL6283185 | 0.83 | ALDH1A1 (0.49) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL6283183 | 0.83 | ALDH1A1 (0.49) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL6925536 | 0.82 | CA1 (0.59) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5638270 | 0.82 | CA1 (0.59) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5638275 | 0.82 | CA1 (0.59) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL11527174 | 0.82 | CA1 (0.59) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL12207830 | 0.82 | CA1 (0.59) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL11064560 | 0.80 | CA1 (0.56) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL21837494 | 0.80 | CA1 (0.60) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004093796-A2 | LACTAM DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |