Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 10/20 | 0.67 |
| ▸ | PDE1C | Q14123 | 7/20 | 0.59 |
| ▸ | PDE5A | O76074 | 3/20 | 0.43 |
| ▸ | PDE1A | P54750 | 3/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6756685 | 0.99 | PDE9A (0.66) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6695826 | 0.93 | PDE9A (0.77) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL5065639 | 0.93 | PDE9A (0.77) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6692160 | 0.84 | PDE9A (0.58) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6695628 | 0.83 | PDE9A (0.57) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6689237 | 0.82 | PDE9A (0.56) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6686774 | 0.82 | PDE9A (0.56) | PDE9APDE1CPDE5APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL6758950 | 0.82 | PDE9A (0.56) | PDE9APDE1CPDE5APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL6875142 | 0.81 | PDE9A (0.55) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6694674 | 0.81 | PDE9A (0.55) | PDE9APDE1CPDE5APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004096811-A1 | PDE9 INHIBITORS FOR TREATING TYPE 2 DIABETES, METABOKIC SYNDROME, AND CARDIOVASCULAR DISEASE | PFIZER PRODUCTS INC. (US) | 2004-11-11 | — | — | WO | claimed |
| US-20040220186-A1 | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease | PFIZER INC. | 2004-11-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220186-A1 | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease | PDE9A, PDE2A, PDE12 | PDE9A 1/4885PDE1C 22/4885PDE5A 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.