SCHEMBL6689280

SCHEMBL6689280

O=C(SCc1ccc(Cl)cc1)C(Cl)(Cl)Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 5/20 0.53
TDP1 Q9NUW8 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
ALDH1A1 P00352 3/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
HPGD P15428 3/20 0.41
POLB P06746 1/20 0.41
ALOX15 P16050 1/20 0.41
MAPK1 P28482 1/20 0.41
HSD17B10 Q99714 1/20 0.41
PTPRG P23470 1/20 0.41
GAA P10253 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CYP2C19 P33261 3/20 0.40
CYP2C9 P11712 2/20 0.40
CYP1A2 P05177 2/20 0.40
LMNA P02545 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11632741 0.78 IDO1 (0.58) IDO1TDP1L3MBTL1ALDH1A1MEN1
SCHEMBL8345822 0.78 TDP1 (0.62) IDO1TDP1L3MBTL1ALDH1A1MEN1
Hydrochloric Acid SCHEMBL11842725 0.76 TDP1 (0.61) IDO1TDP1L3MBTL1ALDH1A1MEN1
SCHEMBL14611678 0.76 IDO1 (0.57) IDO1TDP1L3MBTL1ALDH1A1MEN1
SCHEMBL6689595 0.76 IDO1 (0.68) IDO1TDP1L3MBTL1ALDH1A1MEN1
SCHEMBL15424828 0.73 TDP1 (0.62) IDO1TDP1L3MBTL1ALDH1A1MEN1
SCHEMBL11444333 0.72 IDO1 (0.57) IDO1TDP1L3MBTL1ALDH1A1MEN1
SCHEMBL22767269 0.72 TDP1 (0.65) IDO1TDP1L3MBTL1ALDH1A1MEN1
SCHEMBL10409192 0.72 IDO1 (0.52) IDO1TDP1L3MBTL1ALDH1A1MEN1
Butane SCHEMBL7059838 0.70 IDO1 (0.59) IDO1TDP1L3MBTL1ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004080938-A1 SYNTHESIS OF S-ALKYL AND S-ARYL THIOCARBAMATES, ONE-POT TWO-STEP GENERAL SYNTHESIS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2004-09-23 WO disclosed
US-6686494-B1 PRECURSOR THIOL REAGENT IS FIRST REACTED WITH TRICHLOROACETYL CHLORIDE TO PRODUCE S-ALKYL OR S-ARYL TRICHLOROACETYL THIOESTER INTERMEDIATE, WHICH IS REACTED WITH AN AMINE TO YIELD THIOCARBAMATE PRODUCT THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY 2004-02-03 US disclosed