Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.37 |
| ▸ | FASN | P49327 | 5/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6670101 | 0.86 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6690576 | 0.85 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6701305 | 0.84 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6686207 | 0.78 | NAMPT (0.48) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6670100 | 0.77 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6084464 | 0.75 | MAPT (0.47) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6694405 | 0.73 | SMN1; SMN2 (0.45) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6085906 | 0.73 | MAPT (0.53) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6084633 | 0.72 | CETP (0.46) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL6085303 | 0.72 | MAPT (0.50) | NPC1RAB9ASMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-A1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002062804-A1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2002-08-15 | — | — | WO | disclosed |